At Vivaltes, we utilise C. elegans assays to evaluate the efficacy of cognitive health products. Our ethical models allow for rapid screening of bioactive compounds, nootropics, and neuroprotective agents. Leveraging C. elegans mutants, we examine key cognitive health endpoints, including neuroprotection, synaptic function, stress resilience, and memory-related pathways. To support health claims, we integrate metabolomics and RNA sequencing (RNA-seq) for in-depth molecular insights.
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Its fully mapped connectome allows for precise analysis of neural circuits involved in learning, while its short lifespan enables high-throughput screening of cognitive enhancers or neurodegenerative disease models. Additionally, many genes and signalling pathways regulating cognition are conserved between C. elegans and humans, providing valuable insights into mechanisms underlying learning, memory, and synaptic plasticity.
C. elegans strains can model neurodegenerative diseases, like Huntington's.
C. elegans strains can model neurodegenerative diseases, like Huntington's.
C. elegans strains can be used to investigate neurodegeneration and protection by certain compounds.
Cognitive decline is associated with oxidative stress, mitochondrial dysfunction, and protein aggregation. We utilise disease models of neurodegenerative conditions such as Alzheimer's and Huntington's to assess product effects on neuronal health and cognitive function.
C. elegans models enable the evaluation of neuroprotective compounds by assessing neuronal health, stress resilience, and mitochondrial function.
Lifespan and movement assays provide insight into neurodegenerative processes, while genetic models help identify compounds that promote brain longevity.
C. elegans displays fundamental learning and memory behaviours that are critical for testing cognitive function and evaluating potential cognitive enhancers.
Through the analysis of associative learning and chemotaxis-based memory, we can assess how various compounds influence memory formation, retention, and synaptic plasticity. These behaviours provide valuable insights into the mechanisms of learning and memory at the level of the nervous system.
Learning assays, such as the Alzheimer's memory assay, can demonstrate a compound's cognitive boosting effect by measuring its ability to enhance memory performance and learning capacity in C. elegans.
Heat stress assays in C. elegans evaluate cognitive health by measuring stress responses.
Cognitive health is closely linked to stress adaptation. Using C. elegans, we can determine how compounds enhance neuronal resilience during stress response. The model’s genetic tractability allows us to explore stress response pathways, aiding in the development of products that support mental clarity and cognitive function.
Join Vivaltes in shaping the future of health. Whether you're developing nutraceuticals, plant-based medicines, searching for the next breakthrough in supplement marketing, or seeking ethical testing alternatives, our expertise and cutting-edge technologies are here to support you.
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