Improve compound assessment by using C. elegans and cell-based assays to provide mechanistic insights and human-relevant data.
New Approach Methodologies (NAMs)
Redefining testing through innovation
Vivaltes is revolutionising the future of product development with New Approach Methodologies. By replacing traditional animal testing with a combination of animal-friendly, alternative test methods and AI-solutions, we enable efficient, ethical, and scientifically robust research and innovation.
What are NAMs?
New Approach Methodologies (NAMs) are innovative, non-animal testing strategies that use computational models, in vitro assays, and alternative organisms like C. elegans to assess the biological effects of compounds.
At Vivaltes we adhere to the principles of the 3Rs (Reduce, Replace, Refine), utilising an array of NAMs - including C. elegans, cell-based assays, and computational modeling - to validate the biological activity and safety of your compounds in an animal-friendly manner.
Key benefits
Why choose NAMs?
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Predictive Accuracy
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Ethical Practices
Replace traditional animal models with scientifically validated, animal-free alternatives.
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Cost-Efficiency
Make use of large-scale screening and reduce reliance on animal studies.
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Faster Results
Streamline product development timelines with efficient and scalable solutions.
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Regulatory Compliance
Meet global standards for product safety and efficacy without compromising on ethics.
Applications
Our assays for tailored insights
Our experimental assays are NAMs that can be tailored to your product development needs, offering flexible, reliable, and animal-free solutions for assessing compound activity.
Explore our Experimental Assays page for more details on these tailored solutions.
How it works
Our testing process
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Discovery
We use our proprietary data platform, Herb-Paths, to identify herbal compounds, biological pathways, synergies, and phenotypes relevant to your product requirements.
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Experimental Design
Our experts design customised testing strategies based on Herb-Paths insights to meet your specific research needs.
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NAMs Testing
We test your product or product combinations using our extensive suite of experimental assays.
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Results
We test your product or product combinations using our extensive suite of experimental assays.
Our publications
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Sample Preparation of Caenorhabditis elegans for GC-MS-Based Metabolomics in Toxicity Assessment
Methods in Molecular Biology (2025)
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3′sialyllactose and 6′sialyllactose enhance performance in endurance-type exercise through metabolic adaptation
Food Science & Nutrition (2023)
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DARTpaths, an in silico platform to investigate molecular mechanisms of compounds
Bioinformatics (2022)
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Herb-Paths, a network and statistical model to explore health-beneficial effects of herbs and herbal constituents
BioRXiv (2022)
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C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties
Cannabis Research (2022)
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Towards a Reporting Guideline for Developmental and Reproductive Toxicology Testing in C. elegans and Other Nematodes
Toxicology Research (2021)
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Serum Metabolomic Analysis of Coronary Heart Disease Patients with Stable Angina Pectoris Subtyped by Traditional Chinese Medicine Diagnostics Reveals Biomarkers Relevant to Personalized Treatments
Frontiers in Pharmacology (2021)
Frequently Asked Questions
How does Vivaltes use NAMs to test products?
At Vivaltes, we integrate C. elegans models, cell-based assays, and computational modeling to validate the biological activity, safety, and efficacy of compounds. Our approach provides reliable, high-throughput, and tailored solutions for product development.
What types of products can be tested with NAMs?
We can assess a wide range of products, including pharmaceuticals, nutraceuticals, supplements, food ingredients, and more to determine their biological effects, mechanisms of action, and health implications.
How do NAMs compare to traditional animal testing?
NAMs are faster, more cost-effective, and provide data that is directly relevant to human biology. They also align with ethical and regulatory shifts toward reducing animal testing.
What role does C. elegans play in NAMs testing at Vivaltes?
C. elegans serves as a powerful whole-organism model that allows us to study compound effects on metabolism, neurobiology, aging, and much more while maintaining ethical and cost advantages. Vivaltes also offers cell-based assays in cases where C. elegans-based experiments are insufficient.
Can NAMs be customised for my specific product?
Yes! We design tailor-made testing strategies based on your product’s properties and intended effects, ensuring a precise and relevant evaluation.
What kind of data and insights will I receive from NAMs testing?
You will receive a comprehensive report detailing efficacy, safety, biological impact, and potential mechanisms of action, helping you make informed decisions about product development.
How do NAMs and Herb-Paths work together?
Our proprietary AI-powered platform, Herb-Paths, predicts biological pathways, synergies, and phenotypes of herbal products. Laboratory testing and validation of identified herbal compounds and combinations is executed using our selection of NAMs. Thus, they go hand in hand.
Are NAMs accepted by regulatory authorities?
Regulatory acceptance of NAMs is growing, with agencies like the FDA and OECD recognising their value in certain contexts. We ensure our methodologies align with evolving regulatory standards.
Ethical, predictive, and reliable testing solutions
Looking for alternatives to traditional testing methods? Let’s discuss how our New approach methodologies solutions can support your research while maintaining ethical standards.